ʻO ka manō maʻemaʻe kiʻekiʻe ʻo chondroitin sulfate kahi mea nui no ka mālama olakino hui
ʻO Chondroitin sulfate (CS) kahi glycosaminoglycan koʻikoʻi i hoʻopili pū ʻia me nā protein e hana i nā proteoglycans.Hoʻolaha nui ʻia ia i loko o ka matrix extracellular a me ka ʻili pūnaewele o nā ʻiʻo holoholona, a he mea koʻikoʻi ia o ka ʻiʻo pili holoholona, ʻo ia ka mea nui loa i ka cartilage.Hoʻokumu ʻia ke ʻano kumu o ka chondroitin sulfate ma ka hoʻololi ʻana i ka ligation o D-glucuronic acid a me N-acetylgalactosamine e nā glycosidic bonds, kahi i hoʻopili hou ʻia i ka ʻāpana kumu o ka protein e hana i kahi ʻano proteoglycan paʻakikī.
ʻO ka chondroitin sulfate i loaʻa i ka manō kekahi o ia mea, he waiwai mucopolysaccharide acidic i hoʻomākaukau ʻia mai ka ʻiʻo cartilage manō.ʻIke ʻia ma ke ʻano he pauda keʻokeʻo a keʻokeʻo paha, ʻaʻohe ʻala, ʻono kū ʻole.ʻO Chondroitin shark sulfate kekahi o nā mea nui o ka ʻiʻo pili mammalian, a ʻike nui ʻia i loko o ka cartilage, iwi, tendons, ligaments, sarcolemma, a me nā paia o nā moku koko.
Hana ia ma ke ʻano he paʻa a kākoʻo i ka cartilage articular.Hiki ke kōkua i ka hoʻohana ʻana i ka chondroitin sulfate i ka mālama ʻana i ka ʻiʻo cartilage, hoʻemi i ka pehu a me ka ʻeha, hoʻomaikaʻi i ka hana ʻino a me ka palekana kiʻekiʻe.Hoʻohana pinepine ʻia me ka glucosamine, kahi hui e hoʻomaikaʻi maikaʻi loa i ka ʻeha ʻeha i ka osteoarthritis a hoʻoulu i ka collagen hou a me nā proteoglycans i nā chondrocytes.
| inoa mea kūʻai | Manō Chondroitin Sulfate Soidum |
| Ke kumu | Kumu Manō |
| Kūlana Kūlana | USP40 maʻamau |
| Ka nana aku | Keʻokeʻo i ka pauka keʻokeʻo |
| Helu CAS | 9082-07-9 |
| Kaʻina hana hana | kaʻina hana hydrolysis enzymatic |
| Maʻiʻo Protein | ≥ 90% e CPC |
| Nalo ma ka maloo | ≤10% |
| Maʻiʻo Protein | ≤6.0% |
| Hana | Kākoʻo ola kino hui, Cartilage and Bone Health |
| Palapala noi | ʻO nā meaʻai meaʻai i loko o ka Tablet, Capsules, a i ʻole ka pauda |
| Palapala Halal | ʻAe, Halal Verified |
| Kūlana GMP | NSF-GMP |
| Palapala Ola | ʻAe, loaʻa ka palapala olakino no ke kumu hoʻomaʻemaʻe maʻamau |
| Ola Pahu | 24 mahina mai ka lā hana |
| Hoʻopili | 25KG / Drum, Hoʻopili i loko: PAlua PE BAGS, Hoʻopili waho: Pepa pahu |
| MEA | OLELO HOOLAHA | ANOAI HOAO |
| Ka nana aku | ʻO ka pauda kristal keʻokeʻo keʻokeʻo | Nānā |
| ʻIkepili | Hōʻoia ka laʻana me ka waihona kuhikuhi | Na NIR Spectrometer |
| Pono e hōʻike ʻia ka nui o ka hawewe infrared absorption o ka laʻana i nā lōʻihi hawewe like me ka chondroitin sulfate sodium WS. | Na FTIR Spectrometer | |
| Disaccharides haku mele: ʻO ka lakio o ka pane kiʻekiʻe i ka△DI-4S i ka △DI-6S ʻaʻole i emi iho ma mua o 1.0 | Enzymatic HPLC | |
| Rotation Optical: E hoʻokō i nā koi no ka hoʻololi ʻana i ka optical, ka hoʻololi kikoʻī i nā hoʻokolohua kikoʻī | USP781S | |
| Hōʻike (Odb) | 90%-105% | HPLC |
| Nalo ma ka maloo ana | < 12% | USP731 |
| Polokina | <6% | USP |
| Ph (1%H2o Haʻina) | 4.0-7.0 | USP791 |
| Hoʻololi kikoʻī | - 20°~ -30° | USP781S |
| Ke koena ma ka Ingition (Dry Base) | 20%-30% | USP281 |
| Organic Volatile koena | NMT0.5% | USP467 |
| Sulfate | ≤0.24% | USP221 |
| Klorida | ≤0.5% | USP221 |
| Mālamalama (5%H2o Solution) | <0.35@420nm | USP38 |
| Maʻemaʻe Electrophoric | NMT2.0% | USP726 |
| Ka palena o nā disaccharides kūikawā | <10% | Enzymatic HPLC |
| Metala Kaumaha | ≤10 PPM | ICP-MS |
| Helu Papa Nui | ≤1000cfu/g | USP2021 |
| Huna & Mold | ≤100cfu/g | USP2021 |
| Salmonella | ʻAʻole | USP2022 |
| E.Coli | ʻAʻole | USP2022 |
| ʻO Staphylococcus Aureus | ʻAʻole | USP2022 |
| Ka nui o ka ʻāpana | Hoʻopilikino ʻia e like me kāu mau koi | Ma ka Hale |
| ʻAiʻi Nui | >0.55g/ml | Ma ka Hale |
ʻO ka mea mua, ʻo ka chondroitin sulfate kahi glycosaminoglycan i ʻike nui ʻia ma ka matrix extracellular o nā kiko.I loko o ka iwi, ʻike nui ʻia ma ka ʻaoʻao o nā chondrocytes a he mea nui ia o ka cartilage extracellular matrix.Kōkua ka mea i ka cartilage e loaʻa ai ka wai a me nā meaʻai, no laila e mālama i ka cartilage i ka maʻa a me ka elastic, a kōkua i ka mālama ʻana i ka hana maʻamau o nā hono.
ʻO ka lua, he mea koʻikoʻi ka hopena physiological o ka chondroitin sulfate no ka cartilage articular.Hiki iā ia ke hoʻopaʻa i nā mole wai, hoʻoulu i ka wai i loko o nā molekala proteoglycan, mānoanoa i ka cartilage a hoʻonui i ka nui o ka wai synovial i loko o ka lua hui, lubricating a kākoʻo i ka hui.Ma kēiaʻano, hiki i ka hui ke hoʻemi i ka hakakā a me ka hopena i ka wā e neʻe ai, i hiki i ka hui ke neʻe me kaʻole.
ʻO ka hope, hana pū ka chondroitin sulfate i ka ʻenekinia iwi.Ua hoʻomākaukau ka poʻe noiʻi i nā hydrogels composite e pili ana i ka chondroitin sulfate, kahi e hoʻopaʻa pono ai i nā ion inorganic a hoʻoulu i ka biomineralization iwi, no laila e hoʻonui ai i ka hiki ke hoʻōla hou i nā iwi.He mau noi koʻikoʻi kēia no ka ʻoki ʻana i ke kino o ka maʻi e like me ka hoʻoponopono ʻino iwi a me ka grafting iwi.
1. Hoʻonui i ke olakino hui: ʻO Chondroitin sulfate kekahi o nā mea nui o ka cartilage articular, hiki ke kōkua i ka cartilage articular e mālama i kona elasticity a me ka wai, a pēlā e mālama ai i ka hana maʻamau o ka hui.Ma ka hoʻohui ʻana me ka chondroitin sulfate, hiki iā ia ke hoʻoikaika i ka hoʻoponopono ʻana a me ka hana hou ʻana o ka cartilage articular, no laila e hoʻolōʻihi i ke kaʻina o ka degeneration hui.
2. E ho'ēmi i kaʻeha hui: hiki i ka chondroitin sulfate ke hoʻemi i ka pane inflammatory i ka hui, e ho'ēmi i ka hoʻouluʻana o ka synovium hui, a laila e ho'ēmi i kaʻeha hui.He hopena hoʻomaha koʻikoʻi kēia no nā poʻe maʻi me nā maʻi hui e like me ka arthritis.
3. E hoʻomaikaʻi i ka neʻe ʻana o ka hui: Chondroitin sulfate e hoʻomaikaʻi i ka neʻe ʻana a me ka maʻalahi o ka hui ma o ka hoʻonui ʻana i ka lubrication hui a me ka hōʻemi ʻana i ka friction hui.ʻOi aku ka maʻalahi o ka hui ʻana i ka wā e neʻe ai, e hōʻemi ana i ka pilikia i hana ʻia e ka ʻoʻoleʻa hui a i ʻole ka neʻe ʻana.
4. Mālama i ka cartilage articular: Hiki i ka Chondroitin sulfate ke kāohi i ka hōʻino ʻana o ka cartilage articular, a hoʻoikaika i ka synthesis a me ka huna ʻana o nā chondrocytes, i mea e pāʻani ai i ka pale ʻana i ka cartilage articular.Kōkua kēia i ka hoʻopaneʻe i ke kaʻina o ka ʻelemakule a me ka degeneration.
1. ʻO ka ho'ōla ʻana i ka ʻeha a me ka hoʻoponopono ʻana i ka ʻili: He mea koʻikoʻi ka Chondroitin sulfate i ke kaʻina hana o ka ho'ōla ʻana.Hiki iā ia ke hoʻoikaika i ka hana hou ʻana a me ka hoʻoponopono ʻana i nā ʻiʻo ʻeha, hoʻomaikaʻi i ka elasticity a me ka paʻa o ka ʻili, a kōkua i ka hōʻemi ʻana i ka hoʻokumu ʻana o ka ʻili.No laila, hiki ke hoʻohana ʻia ka chondroitin sulfate i nā kaʻina hana, ka mālama ʻana i ke ahi a me ka hoʻoponopono ʻana i ka ʻili.
2. ʻOihana Hoʻomaʻamaʻa: Ma muli o kāna mau mea momona maikaʻi a me ka hopena anti-aging, hoʻohana nui ʻia ka chondroitin sulfate i ka ʻoihana hoʻonaninani.Hiki ke hoʻohui ʻia i nā huahana mālama ʻili ma ke ʻano he mea hoʻomaʻemaʻe, e kōkua ana i ka mālama ʻana i ke koena o ka ʻili a hoʻomaikaʻi i ka elasticity a me ka nani o ka ʻili.Eia kekahi, hiki i ka chondroitin sulfate ke pale i ka hana ʻana o nā radical manuahi, hoʻolōʻihi i ka hana ʻelemakule o ka ʻili, a ʻoi aku ka maikaʻi o ka ʻili.
3. ʻEnekinia Tissue a me ka lāʻau lapaʻau hou: Ma ke kahua o ka ʻenekinia kiko a me ka lāʻau lapaʻau hou, hoʻohana ʻia ka chondroitin sulfate ma ke ʻano he ʻāpana o ke kūkulu ʻana i nā mea biomimetic stent.Hiki ke hoʻohui ʻia me nā biomaterial ʻē aʻe e hana i nā scaffolds me nā hale a me nā hana kikoʻī no ka hoʻoponopono ʻana a i ʻole ke pani ʻana i nā ʻiʻo a me nā kino i hōʻino ʻia.ʻO ka biocompatibility a me ka bioactivity o ka chondroitin sulfate e lilo ia i moho koʻikoʻi ma ke kahua o ka ʻenekini kiko.
4. Ka hopena antitumor: I nā makahiki i hala iho nei, ua ʻike nā haʻawina e loaʻa ana i ka chondroitin sulfate ka mana antitumor.Hiki iā ia ke pale i ka hoʻomaka ʻana a me ka holomua ʻana ma o ka hoʻoponopono ʻana i ka ulu ʻana, ka ʻokoʻa a me nā kaʻina apoptotic o nā cell tumor.ʻOiai aia ka noiʻi kūpono i ka pae mua, ua manaʻo ʻia ka manaʻolana o ka hoʻohana ʻana i ka chondroitin sulfate ma ke kahua o ka anti-tumor.
ʻAʻole like ka Chondroitin sulfate a me ka glucosamine sulfate.Aia kekahi mau ʻokoʻa i kā lākou haku mele ʻana, hoʻohana a me nā ʻano hana.
ʻO Chondroitin sulfate kahi glycosaminoglycan me nā ʻano hana olaola like ʻole, me ka lipid-regulating a me nā hopena anti-inflammatory.Hoʻohana nui ʻia ia i ka mālama ʻana i ka osteoarthritis a hiki ke hōʻemi i nā mediators inflammatory a me nā kaʻina apoptotic, ʻoiai e hōʻemi ana i ka hana o nā cytokine inflammatory, iNOS a me MMP.Eia kekahi, he hana koʻikoʻi ka chondroitin sulfate i ka pale ʻana a me ka hoʻoponopono ʻana i ka cartilage articular, e kōkua ana i ka cartilage e pale aku i ke koʻikoʻi tensile ma lalo o nā kūlana hoʻouka like ʻole ma o ka hana ʻana i ka ʻiʻo kūpaʻa a elastic.
A ʻo ka glucosamine sulfate kekahi mea nui, i hoʻohana nui ʻia i ka pale ʻana a me ka mālama ʻana i nā ʻano osteoarthritis like ʻole, e like me ka hui kuli a me ka hui pūhaka.Hoʻohana ia i ka cartilage articular, ma ka hoʻoulu ʻana i nā chondrocytes e hana i nā proteoglycans me ka hoʻolālā polysome maʻamau, hoʻomaikaʻi i ka hiki ke hoʻoponopono i nā chondrocytes, kaohi ʻana i nā enzyme cartilage pōʻino e like me collagenase a me phospholipase A2, a hiki ke pale i ka hana ʻana o nā radical manuahi superoxidized i nā pūnae pōʻino. ke kaʻina hana pathological o ka osteoarthritis a me ka holomua o ka maʻi, hoʻomaikaʻi i ka hana hui, hoʻomaha i ka ʻeha.
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