- Hoʻohana i nā mea lapaʻau
- ʻO ka hoʻohana ʻana i ka ʻenekinia kiko
- Hoʻohana i ke kuni
- Noi ka nani
ʻO Collagen kahi ʻano keʻokeʻo, opaque, branchless fibrous protein, ka mea nui i loko o ka ʻili, iwi, cartilage, niho, tendons, ligaments a me nā kīʻaha koko o nā holoholona.He mea koʻikoʻi koʻikoʻi ʻo ia i ka hoʻokumu ʻana o ka ʻiʻo pili, a he kuleana ia i ke kākoʻo ʻana i nā kino a me ka pale ʻana i ke kino.I nā makahiki i hala iho nei, me ka hoʻomohala ʻana o ka ʻenehana hoʻoneʻe collagen a me ka noiʻi hohonu e pili ana i kona ʻano a me nā waiwai, ua ʻike nui ʻia ka hana biological o collagen hydrolysates a me polypeptides.Ua lilo ka noiʻi a me ka hoʻohana ʻana i ka collagen i wahi hotspot noiʻi i ka lāʻau lapaʻau, ka meaʻai, nā mea hoʻonaninani a me nā ʻoihana ʻē aʻe.
ʻO Collagen kahi protein maoli o ke kino.Loaʻa iā ia kahi pilina maikaʻi no nā molekala protein ma ka ʻili o ka ʻili, nāwaliwali antigenicity, biocompatibility maikaʻi a me ka palekana biodegradation.Hiki ke hoʻohaʻahaʻa a hoʻopiliʻia, a he maikaʻi ka pili.ʻO ka suture surgical i hana ʻia me ka collagen ʻaʻole wale ka ikaika kiʻekiʻe e like me ke siliki maoli, akā loaʻa pū kekahi i ka absorbability.Ke hoʻohana ʻia, loaʻa iā ia ka hana platelet aggregation maikaʻi loa, ka hopena hemostatic maikaʻi, ka maʻalahi a me ka elasticity.ʻAʻole wehe ka hui kuʻi, ʻaʻole i hōʻino ʻia ke kino o ke kino i ka wā e hana ai, a ua pili maikaʻi i ka ʻeha.Ma lalo o nā kūlana maʻamau, hiki i ka manawa pōkole o ka hoʻopiʻi ke loaʻa i ka hopena hemostatic maikaʻi.No laila hiki ke hana ʻia ka collagen i ka pauka, palahalaha a me ka spongy hemostatic.I ka manawa like, ʻo ka hoʻohana ʻana i nā mea synthetic a i ʻole collagen i loko o ka plasma substitutes, artificial skin, artificial blood vessels, bone repair and artificial iwi and immobilized enzyme carriers he noiʻi nui loa a me ka noi.
Loaʻa i ka Collagen nā pūʻulu reactive ma kāna kaulahao peptide mole, e like me ka hydroxyl, carboxyl a me nā hui amino, he mea maʻalahi ke komo a hoʻopaʻa i nā ʻano enzymes a me nā cell e hoʻokō i ka immobilization.Loaʻa iā ia nā hiʻohiʻona o ka pilina maikaʻi me nā enzymes a me nā cell a me ka adaptability ikaika.Eia hou, ua maʻalahi ka collagen i ka hana a me ke ʻano, no laila hiki ke hana ʻia ka collagen i hoʻomaʻemaʻe ʻia i nā ʻano mea like ʻole, e like me ka membrane, tape, sheet, sponge, beads, etc.Ma waho aʻe o ka biodegradability, hiki ke hoʻopili i nā kiko, biocompatibility a me nā antigenicity nāwaliwali, hoʻohana nui ʻia ka membrane collagen i ka biomedicine.Loaʻa iā ia nā hiʻohiʻona aʻe: hydrophilicity ikaika, ikaika tensile kiʻekiʻe, morphology like me ka derma-like a me ke ʻano, a me ka permeability maikaʻi i ka wai a me ka ea.Hoʻoholo ʻia ka bioplasticity e ka ikaika tensile kiʻekiʻe a me ka ductility haʻahaʻa;Me nā pūʻulu hana he nui, hiki ke hoʻopaʻa ʻia e hoʻopaʻa i kona helu biodegradation.Hiki ke hoʻololi ʻia (ka pehu);Loaʻa ka hopena synergistic ke hoʻohana ʻia me nā mea bioactive ʻē aʻe.Hiki ke launa pū me nā lāʻau lapaʻau;Hiki ke ho'ēmi i ka antigenicity, hiki ke hoʻokaʻawale i nā microorganism, loaʻa nā hana physiological, e like me ke koko coagulation a me nā pono ʻē aʻe.
ʻO nā palapala noi lapaʻau he wai wai, gel, granule, sponge a me ke kiʻiʻoniʻoni.Pēlā nō, hiki ke hoʻohana ʻia kēia mau ʻano no ka hoʻokuʻu lohi ʻana i nā lāʻau lapaʻau.ʻO nā noi hoʻokuʻu lohi o nā lāʻau collagen i ʻae ʻia no ka mākeke a ke hoʻomohala ʻia nei ka nui o ka nānā ʻana i ka anti-infection a me ka mālama glaucoma i ka ophthalmology, ka mālama kūloko i ka trauma a me ka mālama ʻana i ka maʻi i ka hoʻoponopono ʻeha, cervical dysplasia i ka gynecology a me ka anesthesia kūloko i ka ʻoki. , etc.
Hoʻolaha nui ʻia i loko o nā ʻiʻo āpau o ke kino o ke kanaka, he mea koʻikoʻi ka collagen i nā ʻiʻo āpau a ʻo ia ka extracellular matrix (ECM), ʻo ia kahi mea scaffold kiko maoli.Mai ka hiʻohiʻona o ka noiʻi lapaʻau, ua hoʻohana ʻia ka collagen e hana i nā ʻano ʻano ʻenehana ʻenehana, e like me ka ʻili, ka iwi iwi, ka trachea a me nā scaffolds moku koko.Eia nō naʻe, hiki ke hoʻokaʻawale ʻia ka collagen i ʻelua mau ʻāpana, ʻo ia hoʻi nā scaffolds i hana ʻia me ka collagen maʻemaʻe a me nā scaffolds composite i hana ʻia me nā mea ʻē aʻe.Loaʻa i nā scaffolds ʻenehana collagen maʻemaʻe ka maikaʻi o ka biocompatibility maikaʻi, ka hana maʻalahi, ka plasticity, a hiki ke hoʻoikaika i ka hoʻopili ʻana o ke kelepona a me ka hoʻonui ʻana, akā aia kekahi mau hemahema e like me nā waiwai mechanical maikaʻi ʻole o ka collagen, paʻakikī ke hoʻohālikelike i ka wai, a hiki ʻole ke kākoʻo i ke kūkulu hou ʻana o ka ʻiʻo. .ʻO ka lua, ʻo ka ʻiʻo hou ma ke kahua hoʻoponopono e hana i nā ʻano enzymes, e hydrolyze i ka collagen a alakaʻi i ka wāwahi ʻana o nā scaffolds, hiki ke hoʻomaikaʻi ʻia e ka hoʻopili ʻana a i ʻole ka hui.Ua hoʻohana maikaʻi ʻia nā biomaterial e pili ana i ka collagen i nā huahana ʻenekinia kiko e like me ka ʻili artificial, iwi artificial, cartilage grafts a me nā catheters nerve.Ua hoʻoponopono ʻia nā hemahema o ka cartilage me ka hoʻohana ʻana i nā gel collagen i hoʻokomo ʻia i loko o nā chondrocytes a ua hoʻāʻo ʻia e hoʻopili i nā epithelial, endothelial, a me nā cell corneal i nā sponges collagen e kūpono i ka ʻiʻo corneal.Hoʻohui kekahi i nā pūnaewele kumu mai nā pūnaewele mesenchymal autogenous me ka gel collagen e hana i nā tendon no ka hoʻoponopono posttendinous.
ʻO kahi lāʻau hoʻokuʻu hoʻokuʻu ʻia i hoʻopaʻa ʻia i ka ʻiʻo i haku ʻia me ka dermis a me ka epithelium me ka collagen e like me ka matrix i hoʻohana nui ʻia i nā ʻōnaehana lawe lāʻau me ka collagen ka mea nui, hiki ke hana i ka collagen aqueous solution i nā ʻano like ʻole o nā ʻōnaehana lawe lāʻau.ʻO nā laʻana e pili ana i nā pale collagen no ka ophthalmology, collagen sponges no ke kuni a i ʻole trauma, nā ʻāpana no ka hāʻawi ʻana i ka protein, nā ʻano gel o ka collagen, nā mea hoʻoponopono no ka lawe ʻana i ka lāʻau ma o ka ʻili, a me nā nanoparticles no ka hoʻoili ʻana i ke ʻano.Eia kekahi, hiki ke hoʻohana ʻia ma ke ʻano he substrate no ka ʻenekini kiko e pili ana i ka ʻōnaehana moʻomeheu cell, nā mea scaffold no nā kīʻaha koko artificial a me nā valves, etc.
ʻO nā ʻili ʻili autologous ka maʻamau honua no ka mālama ʻana i ke kuni lua a me ke kolu.Eia nō naʻe, no nā poʻe maʻi me nā wela nui, ʻo ka nele o nā grafts ʻili kūpono i lilo i pilikia koʻikoʻi.Ua hoʻohana kekahi poʻe i nā ʻenehana bioengineering e ulu i ka ʻiʻo ʻili pēpē mai nā ʻili ʻili pēpē.Ho'ōla ke ahi ma nā kekelē like ʻole i loko o 3 pule a hiki i 18 mahina, a ʻo ka ʻili ulu hou e hōʻike ana i ka hypertrophy a me ke kū'ē.ʻO kekahi poʻe i hoʻohana i ka poly-DL-lactate-glycolic acid (PLGA) a me ka collagen maoli e ulu i ʻekolu-dimensional fibroblasts ʻili kanaka, e hōʻike ana: Ua ulu wikiwiki nā kelepona ma ka mesh synthetic a ulu kokoke i ka manawa like i loko a i waho, a me nā cell proliferating a huna. ʻoi aku ka lōkahi o ka matrix extracellular.I ka hoʻokomo ʻia ʻana o ka ʻiʻo i loko o ke kua o ka ʻiole dermal, ua ulu ka ʻiʻo ʻili ma hope o 2 pule, a ua ulu ka ʻiʻo epithelial ma hope o 4 pule.
Hoʻokuʻu ʻia ʻo Collagen mai ka ʻili holoholona, ʻo ka ʻili me ka collagen he hyaluronic acid, chondroitin sulfate a me nā proteoglycan ʻē aʻe, loaʻa iā lākou ka nui o nā pūʻulu polar, he mea moisturizing, a loaʻa ka hopena o ka pale ʻana i ka tyrosine i ka ʻili e hoʻololi i loko. melanin, no laila collagen he moisturizing maoli, keʻokeʻo, anti-wrinkle, freckle a me nā hana ʻē aʻe, hiki ke hoʻohana nui ʻia i nā huahana nani.ʻO ka hui ʻana a me ke ʻano o Collagen ke kumu o ka nani.He ʻano like ko Collagen me ka collagen ʻili kanaka.He pūmua fibrous non-wai-soluble me ke kō.Ua waiwai kona mau mole i ka nui o nā amino acids a me nā pūʻulu hydrophilic, a loaʻa iā ia kekahi hana ma luna a me ka hoʻohālikelike maikaʻi.Ma 70% haʻahaʻa haʻahaʻa, hiki iā ia ke mālama i 45% o kona kaumaha ponoʻī.Ua hōʻike ʻia nā hoʻāʻo e hiki i kahi hopena maʻemaʻe o 0.01% collagen ke hana i kahi papa mālama wai maikaʻi, e hāʻawi ana i ka wai āpau e pono ai ka ʻili.
Me ka hoʻonui ʻana o ka makahiki, e emi ana ka hiki synthetic o fibroblast.Inā nele ka ʻili i ka collagen, e hoʻopaʻa pū ʻia nā kolagen fibers, e hopena i ka emi ʻana o nā mucoglycans intercellular.E nalowale ka ʻili i kona palupalu, elasticity a me ka luster, e hopena i ka ʻelemakule.Ke hoʻohana ʻia ʻo ia ma ke ʻano he mea hana i nā mea hoʻonaninani, hiki i ka mea hope ke hoʻolaha i ka papa hohonu o ka ʻili.ʻO ka tyrosine i loko e hoʻokūkū me ka tyrosine i loko o ka ʻili a hoʻopaʻa i ke kikowaena catalytic o tyrosinase, no laila ke keʻakeʻa nei i ka hana ʻana o ka melanin, hoʻonui i ka hana o ka collagen i loko o ka ʻili, mālama i ka wai o ka stratum corneum a me ka pololei o ka hoʻolālā fiber. , a me ka paipai ʻana i ka metabolism o ka ʻiʻo ʻili.He maikaʻi ka moisturizing a me ka moisturizing hopena ma ka ʻili.I nā makahiki 1970 mua, ua hoʻokomo mua ʻia ka bovine collagen no ka injection i ʻAmelika Hui Pū ʻIa e wehe i nā kiko a me nā wrinkles a hoʻoponopono i nā ʻōpala.
Ka manawa hoʻouna: Jan-04-2023